Table 4.
Associations between baseline apo B, LDL-C, non-HDL-C, and apo B concordance/discordance with LDL-C and non-HDL-C with incident CAC > 0 through examination 5 among participants with CAC = 0 at the baseline (N = 2216)
| Minimally-adjusted |
Fully-adjusted |
||||
|---|---|---|---|---|---|
| N CAC > 0/Total N | RR (95% CI)* | P | RR (95% CI)† | P | |
| Individual measures | |||||
| Apo B tertiles | |||||
| <96.9 mg/dL | 203/811 | Reference | Reference | ||
| 96.9–118.0 mg/dL | 237/735 | 1.30 (1.12, 1.52) | <.001 | 1.27 (1.08, 1.48) | .003 |
| >118.0 mg/dL | 270/670 | 1.53 (1.32, 1.78) | <.001 | 1.48 (1.27, 1.74) | <.001 |
| LDL-C tertiles | |||||
| <106.0 mg/dL | 204/766 | Reference | Reference | ||
| 106.0–129.0 mg/dL | 229/723 | 1.21 (1.04, 1.41) | .01 | 1.20 (1.03, 1.39) | .02 |
| >129.0 mg/dL | 277/727 | 1.41 (1.22, 1.62) | <.001 | 1.37 (1.19, 1.58) | <.001 |
| Non-HDL tertiles | |||||
| <129.0 mg/dL | 197/782 | Reference | Reference | ||
| 129.0–136.0 mg/dL | 244/734 | 1.33 (1.15, 1.55) | <.001 | 1.29 (1.10, 1.51) | .001 |
| >136.0 mg/dL | 269/700 | 1.45 (1.25, 1.68) | <.001 | 1.38 (1.18, 1.62) | <.001 |
| Discordance by residual‡ | |||||
| Apo B/LDL-C | |||||
| Discordant low | 168/617 | 0.85 (0.73, 0.99) | .04 | 0.86 (0.73, 1.01) | .06 |
| Concordant | 357/1098 | Reference | Reference | ||
| Discordant high | 185/501 | 1.08 (0.94, 1.24) | .30 | 1.00 (0.84, 1.19) | .99 |
| Apo B/non-HDL-C | |||||
| Discordant low | 178/604 | 0.93 (0.79, 1.08) | .32 | 0.91 (0.78, 1.06) | .23 |
| Concordant | 336/1089 | Reference | Reference | ||
| Discordant high | 196/523 | 1.17 (1.02, 1.34) | .03 | 1.13 (0.98, 1.30) | .09 |
Apo B, apolipoprotein B; CAC, coronary artery calcium; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; non-HDL-C, non-high-density lipoprotein cholesterol.
Relative risk regression model adjusted for age, sex, and race/ethnicity (white, black, Chinese, Hispanic), smoking status (never, former/current), hypertension (yes/no).
Relative risk regression model adjusted for age, sex, and race/ethnicity (white, black, Chinese, Hispanic), smoking status (never, former/current), hypertension (yes/no), body mass index, diabetes (yes/no), triglycerides (log-transformed).
Discordant low = residual difference, <25th percentile; discordant high = residual difference >75th percentile; concordant = residual difference 25th–75th percentile.