Table 5.
Odds ratios for associations of baseline apo B, LDL-C, non-HDL-C and apo B concordance/discordance with LDL-C and non-HDL-C with CAC progression (absolute change/year) relative to no progression through visit 5 (N=3947)
| Minimally adjusted |
Fuly adjusted |
|||||||
|---|---|---|---|---|---|---|---|---|
| >0–<75th percentile* | >75th percentile* | >0 - <75th percentile* | >75th percentile* | |||||
| N>0–<75th | N>75th | OR (95% CI)† | OR (95% CI)† | P‡ | OR (95% CI)∥ | OR (95% CI)∥ | P‡ | |
| Individual measures | <.001 | |||||||
| Apo B tertiles | <.001 | |||||||
| <96.9 mg/dL | 401 | 293 | Ref | Ref | Ref | Ref | ||
| 96.9–118.0 mg/dL | 439 | 401 | 1.38 (1.14, 1.66) | 1.84 (1.47, 2.29) | 1.36 (1.12, 1.65) | 1.72 (1.37, 2.16) | ||
| >118.0 mg/dL | 496 | 409 | 1.97 (1.63, 2.39) | 2.58 (2.06, 3.24) | 1.92 (1.56, 2.37) | 2.37 (1.86, 3.03) | ||
| LDL-C tertiles | <.001 | <.001 | ||||||
| <106.0 mg/dL | 387 | 323 | Ref | Ref | Ref | Ref | ||
| 106.0–129.0 mg/dL | 440 | 376 | 1.33 (1.10, 1.61) | 1.44 (1.16, 1.80) | 1.31 (1.08, 1.59) | 1.39 (1.11, 1.74) | ||
| >129.0 mg/dL | 509 | 404 | 1.81 (1.50, 2.19) | 2.03 (1.63, 2.53) | 1.76 (1.46, 2.14) | 1.98 (1.58, 2.48) | ||
| Non-HDL tertiles | <.001 | <.001 | ||||||
| <129.0 mg/dL | 385 | 311 | Ref | Ref | Ref | Ref | ||
| 129.0–136.0 mg/dL | 447 | 383 | 1.49 (1.23, 1.80) | 1.73 (1.39, 2.16) | 1.46 (1.20, 1.78) | 1.56 (1.24, 1.97) | ||
| >136.0 mg/dL | 504 | 409 | 1.91 (1.58, 2.32) | 2.25 (1.80, 2.81) | 1.87 (1.51, 2.31) | 2.04 (1.60, 2.61) | ||
| Discordance by residual§ | ||||||||
| Apo B/LDL-C | .007 | .69 | ||||||
| Discordant low | 325 | 255 | 0.85 (0.71, 1.03) | 0.92 (0.74, 1.14) | 0.90 (0.75, 1.10) | 1.03 (0.82, 1.29) | ||
| Concordant | 679 | 537 | Ref | Ref | Ref | Ref | ||
| Discordant high | 332 | 311 | 1.13 (0.93, 1.38) | 1.39 (1.11, 1.72) | 1.00 (0.80, 1.25) | 1.10 (0.85, 1.41) | ||
| Apo B/non-HDL-C | .002 | .02 | ||||||
| Discordant low | 318 | 255 | 0.88 (0.73, 1.06) | 0.95 (0.76, 1.18) | 0.87 (0.72, 1.04) | 0.93 (0.74, 1.16) | ||
| Concordant | 679 | 544 | Ref | Ref | Ref | Ref | ||
| Discordant high | 339 | 304 | 1.21 (1.00, 1.46) | 1.46 (1.17, 1.81) | 1.16 (0.95, 1.41) | 1.35 (1.08, 1.69) | ||
apo B, apolipoprotein B; CAC, coronary artery calcium; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; non-HDL-C, non–high-density lipoprotein cholesterol.
75th percentile cut-point = 16.44 Agatstons increase/year.
Multinomial logistic regression model with log-transformed CAC as dependent variable adjusted for age, sex, race/ethnicity (White, Black, Chinese, Hispanic), smoking status (never, former/current), hypertension (yes/no).
Wald X2 for overall type 3 analysis of effects.
Discordant low = residual difference <25th percentile; discordant high = residual difference >75th percentile; concordant = residual difference 25th–75th percentile.
Multinomial logistic regression model with log-transformed CAC as dependent variable adjusted for age, sex, race/ethnicity (White, Black, Chinese, Hispanic), smoking status (never, former/current), hypertension (yes/no), body mass index, diabetes (yes/no).