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. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Oncogene. 2020 Jan 27;39(12):2583–2596. doi: 10.1038/s41388-020-1167-x

Figure 5: FBR region of PACS-1 is essential for its interaction with HDACs.

Figure 5:

A) Full length (963a.a.) PACS-1 protein is divided in to N-term (1–499a.a.) and C-term (500–963a.a.). N-term is further divided into ARR (1–117a.a.), FBR (117–263a.a.) and MR (240–499a.a.). B) PACS-1 downregulated HeLa cells were complemented with Myc-tagged N-terminal, C-terminal and full length PACS-1. Interestingly, full length PACS-1-Myc and N-terminal PACS-1-Myc brought back the HDAC2 and HDAC3 levels and reduced the γH2AX formation in PACS-1 downregulated cells. C) IP results show that FBR region of PACS-1-Myc binds to the HDAC3.