Skip to main content
. Author manuscript; available in PMC: 2020 Jul 27.
Published in final edited form as: Oncogene. 2020 Jan 27;39(12):2583–2596. doi: 10.1038/s41388-020-1167-x

Figure 7: PACS-1 promotes malignant behavior of cancer cells and a poor prognostic marker.

Figure 7:

A) PACS-1 downregulated HeLa cells were complemented with GFP-PACS-1 HDACmut. B) Fiber Assay and C) Chromosomal Aberrations in PACS-1 downregulated HeLa cells complemented with GFP-PACS-1 HDACmut. D) A hypothetical model showing PACS-1 protein, which is mostly present in the cytoplasm, accumulates into the nucleus during S-phase of the cell cycle and during genotoxic stress. Nuclear localized PACS-1 then interacts and stabilizes HDAC2 and HDAC3, which otherwise induces replication stress and genomic instability. *p < 0.05; ***p < 0.001; **** p < 0.0001.