. Author manuscript; available in PMC: 2021 Apr 1.

Published in final edited form as: Cerebellum. 2020 Apr;19(2):217–225. doi: 10.1007/s12311-019-01099-1

Table 2.

Linear regression models to study the associations between baseline cerebellar volume and covariates with baseline cognition

	ADAS-Cog13		ADAS-Cog11
	NC + MCI + AD (n = 802)		NC + MCI + AD (n = 802)
Characteristics	β	p-value	β	p-value
Education (years)	−0.02	0.001	−0.02	0.005
Female	0.001	0.97	0.007	0.87
Age (decades)	−0.07	0.02	−0.06	0.03
APOE4 positivity ^a	0.004	0.94	0.003	0.97
MCI (vs. Normal)	0.62	<0.001	0.46	< 0.001
AD (vs. Normal)	1.41	<0.001	1.18	< 0.001
Cerebellar volume ^b	0.05	0.04	0.04	0.09
Hippocampal volume ^c	−0.22	<0.001	−0.20	<0.001

APOE: Apolipoprotein E gene, ADAS-Cog = Alzheimer’s Disease Assessment Scale-cognitive subscale, NC = normal cognition, MCI = minimal cognitive impairment, AD = Alzheimer’s disease.

Zero copy of E4 = 0, One or two copies of E4 = 1

Standardized ratio of bilateral cerebellum / intracranial volume

Standardized ratio of bilateral hippocampi / intracranial volume

Age is centered at the sample mean. Cognitive measures were transformed into z-scores.