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. 2019 Nov 25;476(3):455–463. doi: 10.1007/s00428-019-02684-9

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Osteoid osteoma and osteoblastoma. Hematoxylin & Eosin (H&E) staining of the nidus of osteoid osteoma a and osteoblastoma b. Regular deposited trabeculae of woven bone are surrounded by active osteoblasts. Both osteoid osteoma and osteoblastoma show strong and diffuse nuclear expression of FOS. Osteoclast-like giant cells are negative (arrow) c and d. Fluorescence in situ hybridization (FISH) using split-apart probes for FOS shows a segregated red and green signal in both osteoid osteoma and osteoblastoma, indicating a FOS rearrangement e and f. Scale bar, 50 μm a–d. Scale bar, 5 μm e and f