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. 2019 Nov 25;476(3):455–463. doi: 10.1007/s00428-019-02684-9

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© The Author(s) 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — High-grade osteoblastic osteosarcoma. H&E staining shows atypical tumor cells depositing lace-like osteoid (H&E) (A). Immunohistochemistry for FOS shows moderate to strong nuclear staining of the tumor cells (B). Additional FISH for FOS and FOSB shows gains of the FOS- and FOSB-locus, respectively (C and D). Scale bar, 50 μm (A and B). Scale bar, 5 μm (C and D)