Table 2.
Comparison of antigenicity between spike glycoproteins of 2019-nCoV and SARS-CoV strains
| Antigenicity | |||||
|---|---|---|---|---|---|
| 2019-nCoV | SARS-CoV | ||||
| Peptides (IEDB) | Peptides (NetCTL 1.2) | Position (start) | Peptides (IEDB) | Peptides (NetCTL 1.2) | Position (start) |
| NSFTRGVYY | NSFTRGVYY | 30 | FDDVQAPNY | FDDVQAPNY | 22 |
| STQDLFLPF | STQDLFLPF | 50 | HTSSMRGVY | HTSSMRGVY | 33 |
| VLPFNDGVY | VLPFNDGVY | 83 | TSSMRGVYY | TSSMRGVYY | 34 |
| CNDPFLGVY | CNDPFLGVY | 136 | EIFRSDTLY | EIFRSDTLY | 45 |
| WMESEFRVY | WMESEFRVY | 152 | RSDTLYLTQ | RSDTLYLTQ | 48 |
| YSSANNCTF | YSSANNCTF | 160 | LTQDLFLPF | LTQDLFLPF | 54 |
| SANNCTFEY | SANNCTFEY | 162 | TQDLFLPFY | TQDLFLPFY | 55 |
| FVFKNIDGY | FVFKNIDGY | 192 | VIPFKDGIY | VIPFKDGIY | 80 |
| NIDGYFKIY | NIDGYFKIY | 196 | HTMIFDNAF | HTMIFDNAF | 149 |
| WTAGAAAYY | WTAGAAAYY | 258 | NAFNCTFEY | NAFNCTFEY | 155 |
| GAAAYYVGY | GAAAYYVGY | 261 | ISDAFSLDV | ISDAFSLDV | 164 |
| ITDAVDCAL | ITDAVDCAL | 285 | FKNKDGFLY | FKNKDGFLY | 187 |
| LSETKCTLK | LSETKCTLK | 296 | NKDGFLYVY | NKDGFLYVY | 189 |
| NATRFASVY | NATRFASVY | 343 | GTSAAAYFV | GTSAAAYFV | 246 |
| RISNCVADY | RISNCVADY | 357 | SAAAYFVGY | SAAAYFVGY | 248 |
| CVADYSVLY | CVADYSVLY | 361 | NATKFPSVY | NATKFPSVY | 330 |
| NSASFSTFK | NSASFSTFK | 370 | RISNCVADY | RISNCVADY | 344 |
| ASFSTFKCY | ASFSTFKCY | 372 | CVADYSVLY | CVADYSVLY | 348 |
| FTNVYADSF | FTNVYADSF | 392 | TSFSTFKCY | TSFSTFKCY | 359 |
| VGGNYNYLY | VGGNYNYLY | 445 | FSNVYADSF | FSNVYADSF | 379 |
| ERDISTEIY | ERDISTEIY | 465 | ATSTGNYNY | ATSTGNYNY | 430 |
| TSNQVAVLY | TSNQVAVLY | 604 | STGNYNYKY | STGNYNYKY | 432 |
| YQDVNCTEV | YQDVNCTEV | 612 | CTPPAPNCY | CTPPAPNCY | 467 |
| QLTPTWRVY | QLTPTWRVY | 628 | FYTTSGIGY | FYTTSGIGY | 483 |
| AEHVNNSY | AEHVNNSY | 653 | TSGIGYQPY | TSGIGYQPY | 486 |
| VASQSIIAY | VASQSIIAY | 687 | FTDSVRDPK | FTDSVRDPK | 558 |
| KTSVDCTMY* | KTSVDCTMY* | 733 | ASSEVAVLY | ASSEVAVLY | 590 |
| STECSNLLL* | STECSNLLL* | 746 | SSEVAVLYQ | SSEVAVLYQ | 591 |
| ECSNLLLQY* | ECSNLLLQY* | 748 | CTDVSTLIH | CTDVSTLIH | 603 |
| RSFIEDLLF | RSFIEDLLF | 815 | QLTPAWRIY | QLTPAWRIY | 614 |
| LTDEMIAQY* | LTDEMIAQY* | 865 | GAEHVDTSY | GAEHVDTSY | 638 |
| GTITSGWTF | GTITSGWTF | 880 | TSQKSIVAY | TSQKSIVAY | 669 |
| RVDFCGKGY | RVDFCGKGY | 1039 | LGADSSIAY | LGADSSIAY | 681 |
| FVSNGTHWF | FVSNGTHWF | 1095 | KTSVDCNMY* | KTSVDCNMY* | 715 |
| VSNGTHWFV | VSNGTHWFV | 1096 | STECANLLL* | STECANLLL* | 728 |
| MTSCCSCLK | MTSCCSCLK | 1237 | ECANLLLQY* | ECANLLLQY* | 730 |
| VLKGVKLHY | VLKGVKLHY | 1264 | RSFIEDLLF | RSFIEDLLF | 797 |
| – | – | – | LTDDMIAAY* | LTDDMIAAY* | 847 |
| – | – | – | GTATAGWTF | GTATAGWTF | 862 |
| – | – | – | TTSTALGKL | TTSTALGKL | 922 |
| – | – | – | RVDFCGKGY | RVDFCGKGY | 1021 |
| – | – | – | MTSCCSCLK | MTSCCSCLK | 1219 |
| – | – | – | VLKGVKLHY | VLKGVKLHY | 1246 |
The table shows a comparison of predicted CTL epitopes in Spike glycoprotein of Wuhan-Hu-1-2019 novel coronavirus (2019-nCoV) and SARS coronavirus-2003(SARS-CoV) strains. Epitopes were generated by NetCTL 1.2 [22] and validated by IEDB Analysis Resource server [23] where scores > 1.25 shows highest sensitivity and specificity towards MHC class I. Italics indicates the identical CTL epitopes
*Italics showing common epitopes with one amino acid change between the two spike glycoproteins