Table 6.
Occurrence of secretion system components in ten Treponema species with numbers of transport proteins in both pathogenic and non-pathogenic strains. Transporters marked in purple are pathogen-specific; those marked in green are specific to non-pathogens, and those in orange are present in both pathogens and non-pathogens.
| Number of constituent proteins | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Family | TCID | Function | Tde | Tpal | Tpe | Tpr | Taz | Tsu | Tpar | Tbr | Tca | Tpu |
| T1SS | 3.A.1.105.7 | Drug exporter (3 components) | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| 3.A.1.105.16 | Unknown exporter (3 components) | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 3.A.1.121.4 | Drug (fluoroquinolones) exporter (2 components) | 2 | 1 | 1 | 4 | 2 | 1 | 1 | 0 | 1 | 3 | |
| 3.A.1.122.1 | Drug (macrolides) exporter (2 components) | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 5 | |
| 3.A.1.122.2 | Peptide (antimicrobials) exporter (4 components) | 2 | 1 | 1 | 2 | 0 | 0 | 2 | 5 | 2 | 2 | |
| 3.A.1.122.12 | Drug (arthrofactin) exporter (2 components) | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
| 3.A.1.122.14 | Unknown exporter (2 components) | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 2 | |
| 3.A.1.122.16 | Drug (macrolides) exporter (2 components) | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | |
| 3.A.1.125.1 | Protein (lipoproteins) exporter (3 components) | 1 | 2 | 2 | 2 | 3 | 1 | 2 | 2 | 1 | 3 | |
| 3.A.1.125.5 | Unknown exporter (2 components) | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | |
| 3.A.1.132.3 | Unknown exporter (2 components) | 1 | 0 | 0 | 2 | 0 | 3 | 0 | 3 | 1 | 1 | |
| 3.A.1.132.6 | Unknown exporter (2 components) | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | |
| T2SS (GSP) | 3.A.5.1.1 | SEC-SRP complex (8 components) | 6 | 5 | 5 | 5 | 6 | 6 | 5 | 7 | 6 | 6 |
| T3SS | 3.A.6.1.1 | Type III protein secretion complex (22 components) | 3 | 1 | 1 | 2 | 1 | 4 | 1 | 0 | 1 | 2 |
| 3.A.6.1.2 | Type III secretion complex (10 components | 6 | 8 | 8 | 7 | 0 | 0 | 0 | 1 | 1 | 0 | |
| T4SS | 3.A.7.7.1 | Conjugal DNA protein transfer system or ViRB (15 components) | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
| 3.A.7.11.1 | Type IV betaproteobacterial DNA secretion system (20 components) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| 3.A.7.13.2 | Conjugal DNA protein transfer system or VIRB (12 components) | 2 | 3 | 3 | 2 | 0 | 1 | 2 | 0 | 1 | 1 | |
| 3.A.7.14.2 | Type IV (conjugal DNA-protein transfer) (11 components) | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | |
| 3.A.7.19.1 | Conjugal DNA protein transfer system or VIRB (19 components) | 1 | 1 | 1 | 3 | 0 | 6 | 1 | 2 | 3 | 2 | |
| T6SS | 3.A.23.1.1 | T6SS VasA-L (14 components) | 4 | 2 | 2 | 6 | 6 | 3 | 2 | 3 | 10 | 5 |
| 3.A.23.6.1 | T6SS (21 components) | 3 | 1 | 1 | 3 | 3 | 6 | 1 | 3 | 3 | 4 | |