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. Author manuscript; available in PMC: 2020 Mar 22.
Published in final edited form as: Microb Pathog. 2019 Apr 25;132:87–99. doi: 10.1016/j.micpath.2019.04.034

Table 7.

Transport proteins that may play roles in the parasitic lifestyle of Treponema pallidum sea 81-4.1

Transport protein name TCID Uniport ID Proposed function
Treponema repeat protein K (TprK) 1.B.38.1.2 Q84AM6 Plays a role in immune evasion and persistence
Glycine/alanine/asparagine/glutamine (AgcS) uptake porter 2.A.25.1.9 W0WFC6 Uptake of amino acids
Galactose/glucose (methyl galactoside) porter (3 components) 3.A.1.2.3 P0AAG8, P0AEE5, P23200 Transport of glucose and galactose
Purine nucleoside permease (PnrABCDE) (5 components) 3.A.1.2.10 083340-43, P29724 Uptake of nucleosides; assists in replication
Manganese (Mn2+), zinc (Zn2+) and possibly iron (Fe2+) uptake porter: TroABCD 3.A.1.15.8 P96116-119 Transport of metal ions
L-Histidine uptake porter MetlQN (3-components) 3.A.1.24.5 Q9HT68, Q9HT69, Q9HT70 Uptake of amino acids
Carnitine/crotonobetaine CoA synthase 4.C.1.1.6 P31552 May assist in the survival of Tpal in the host
1

This list is not exhaustive, and includes those proteins that we presume to assist Tpal to thrive as a parasitic bacterium; future research will certainly expand the number of these transport proteins.