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. 2020 Mar 17;13:2319–2331. doi: 10.2147/OTT.S236860

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© 2020 Xiu et al.

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Knockdown of TUG1 enhanced radiosensitivity of PCa cell lines. (A) TUG1 expression in PC-3 and DU145 cells transfected with si-NC or si-TUG1 was detected by qRT-PCR analysis. (B and C) The cell viability of transfected PC-3 and DU145 cells at 0 hrs, 24 hrs, 48 hrs and 72hrs after radiation treatment. (D) Cell apoptosis was determined in transfected PC-3 and DU145 cells at 24 hrs after 4 Gy of radiotherapy. (E and F) The expression levels of apoptosis-related proteins (Bcl-2, Bax and cleaved-casp-3) were examined by Weston blot in PC-3 and DU145 cells transfected with si-NC or si-TUG1 at 24 hrs after 4 Gy of radiotherapy. (G and H) The clonogenic survival curve was established in Clonogenic assay after transfected PC-3 and DU145 cells subjected to 0, 2, 4, 6 and 8 Gy of irradiation. *P < 0.05.