Table 4.

Human glaucoma pathogenic pathways confirmed in mice

Gene	Pathway	Human	Mouse
MYOC mutations	ER stress	Stone et al., 1997	Shepard et al., 2007
TGFβ2	TGFβ2 fibrotic pathway	Tripathi et al., 1994	Shepard et al., 2010
CTGF	TGFβ2 fibrotic pathway	Junglas et al., 2009 Wallace et al., 2013	Junglas et al., 2012
GREM1	TGFβ2 and BMP pathways	Fuchshofer et al., 2007 Wordinger et al., 2007	Wordinger et al., 2007 McDowell et al., 2015
SFRP1	Wnt β-catenin pathway	Wang et al., 2008a	Wang et al., 2008a
CD44	To be determined	Knepper et al., 2002 Nolan et al., 2007	Giovingo et al., 2013