Table 2.
Individual efficacy responses.
| Included patients | |||
|---|---|---|---|
| Patient #1 | Patient #2 | Patient #3 | |
| Maintenance dose | Medium | High | High |
| Underlying cause of ISS | MCD | Unknown | Unknown MCD found after the study |
| Previous AED | VPA, LTG, LVT | ||
| AED at inclusion | VPA 26 mg/kg/d, LTG 1.7 mg/kg/d, VGB 130 mg/kg/d, Prednisolone 10 mg/d | VGB 130 mg/kg/d prednisolone 10 mg/d | VGB 146 mg/kg/d prednisolone 20 mg/d |
| Clinical responder | Y | N | N |
| Electroclinical responder | Y | N | N |
| Time to cessation of spasms for clinical responders (days) | 6 | NA | NA |
| Interictal EEG at Baseline | Slow waves | Hypsarrhythmia | Fragmented |
| Right fast rhythm | Post Spikes | Hypsarrhythmia | |
| L Temp Spikes | |||
| Interictal EEG at the end of the maintenance period | No change | No change | No change |
| Extended clinical responder | Y | NA | NA |
| Extended electroclinical responder | Y | NA | NA |
| Clinical relapse | N | NA | NA |
| Clinical worsening with radiprodil withdraw | NA | Y | Y |
| Last follow‐up | |||
| Time after inclusion | M11 | M10 | M10 |
| Clinical follow‐up | Spasm‐free | Spasms‐free | Spasms‐free |
| AEDs | VPA, LTG | FLB, KD | VPA, LTG, FLB, KD Surgery |
AED, antiepileptic drug; FLB, felbamate; KD, ketogenic diet; LTG, lamotrigine; LVT, levetiracetam; MCD, Malformation of cortical development; N, No; NA, not applicable; VGB, vigabatrin; VPA, valproate; Y, Yes.