Table 4.

Altered protein distribution in the neuroanatomical predilection areas in PART

Age group (year)	n	BW (g)		HPτ												Aβ
				Tem		Hip.A		Hip.M			Hip.P		LPI	Sum		Men			Par		Occ		Sum
50–59	3	1240±295		2 (67)		1 (33)		2 (67)			1 (33)		0 (0)	3 (100)		0 (0)			0 (0)		0 (0)		0 (0)
60–69	10	1290±120		4 (40)		5 (50)		9 (90)			5 (50)		1 (10)	10 (100)		0 (0)			0 (0)		0 (0)		0 (0)
70–79	13	1176±79		7 (54)		10 (77)		12 (92)			6 (46)		1 (8)	13 (100)		0 (0)			1 (8)		0 (0)		1 (8)
80–89	13	1158±130		4 (31)		9 (69)		12 (92)			6 (46)		1 (8)	13 (100)		0 (0)			0 (0)		0 (0)		0 (0)
≥90	7	1133±81		2 (29)		7 (100)		6 (86)			3 (43)		0 (0)	7 (100)		1 (14)			1 (14)		1 (14)		1 (14)
Total	46	1184±138		19 (41)		32 (70)		41 (89)			21 (46)		3 (7)	46 (100)		1 (2)			2 (4)		1 (2)		2 (4)
Age group (year)		αS*								TDP43							p62
		AE	SN		MO		Sum		AE			Hip.M			Sum		Tem			Hip.M		Sum
50–59	0 (0)		0 (0)		0 (0)		0 (0)		0 (0)			0 (0)			0 (0)		0 (0)			0 (0)		0 (0)
60–69	0 (0)		0 (0)		0 (0)		0 (0)		2 (20)			5 (50)			6 (60)		3 (30)			4 (40)		5 (50)
70–79	0 (0)		0 (0)		0 (0)		0 (0)		3 (23)			7 (54)			7 (54)		5 (38)			9 (69)		10 (77)
80–89	0 (0)		1 (8)		2 (15)		2 (15)		10 (76)			10 (76)			12 (92)		6 (46)			9 (69)		10 (76)
≥90	0 (0)		0 (0)		0 (0)		0 (0)		6 (86)			6 (86)			6 (86)		3 (71)			7 (100)		7 (100)
Total	0 (0)		1 (2)		2 (4)		2 (4)		21 (46)			28 (61)			31 (67)		17 (37)			29 (63)		32 (70)

Data are presented as mean±standard error (SE), number (percentage), or number.

^*αS-positive except Parkinson’s disease cases. PART, primary age-related tauopathy; BW, brain weight; HPτ, hyperphosphorylated-τ; Aβ, β-amyloid; αS, α-synuclein; TDP43, transactive response DNA-binding protein 43; Tem, temporal pole; Hip.A, hippocampus anterior; Hip.M, hippocampus middle; Hip.P, hippocampus posterior; LPI, lobulus parietalis superior; Men, meninges; Par, parietal; Occ, occipital pole; AE, amygdala/entorhinal cortex; SN, substantia nigra; MO, medulla oblongata