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Summary of pKa values observed and proposed chemical events associated with them
aCarboxyl of free 3F4HPA is shown.
b(EH) indicates that the proposed nearby enzyme active-site residue is protonated.
c(E) indicates that the proposed nearby enzyme active-site residue is not protonated.
d(L) indicates that the deprotonated state of ligand is bound, and imH indicates deprotonation of the imidazolium side chain of His.
eFixing pKa of 9.0 for free 3F4HPA is shown.
