Table 1.

Summary of confirmed hits with calculable IC₅₀ values from the Prestwick library screen in the rat cortical tau inclusion assay

Data are provided showing the inhibitory activity of each compound on tau inclusions and DAPI nuclei from the original screen (10 μm compound) and tau inclusion, DAPI, MAP2 and NeuN inhibitory activity in the triplicate confirmation analyses (10 μm compound). In addition, the calculated tau aggregate IC₅₀ values and maximal inhibition from concentration–response testing are listed for each compound. Finally, the inhibitory activities of the compounds as measured in the orthogonal tau multimer (mTau8) ELISA are shown, with each compound tested at the approximate IC₉₀ concentration (except Alfuzosin, tested at IC₅₀).