Table 1. Pharmacokinetic-pharmacodynamic parameters of the Kim model.
| Variables | Parameters | Estimate |
|---|---|---|
| PK | V1, L | 1.69 |
| V2, L | 27.2 + 0.93 × (weight − 25) | |
| Cl, L/min | 0.89 × (weight/23.6)0.97 | |
| Q, L/min | 1.3 | |
| PD (intermediate) | E0 | 76.9 |
| Emax | 35.4 | |
| Ce50, μg/mL | 3.78 − 0.183 × AGE | |
| γ | 3.02 | |
| ke0, /min | 0.557 | |
| PD (final) | E0 | 79.9 |
| Emax | 30.6 | |
| Ce50, μg/mL | 3.65 − 0.102 × AGE − 1.72 × REMI | |
| γ | 3.02 | |
| ke0, /min | 0.557 |
PK = pharmacokinetic, PD = pharmacodynamic, V1 = central volume of distribution, V2 = peripheral volume of distribution, Cl = metabolic clearance, Q = inter-compartmental clearance, E0 = baseline bispectral index value before propofol administration, Emax = minimum possible bispectral index value, Ce50 = Ce at 50% of the maximal propofol effect on Bispectral Index, AGE = age (yr), ã = steepness of the Ce versus bispectral index relationship, ke0 = blood-brain equilibration rate constant, REMI = mean infusion rate of remifentanil throughout the operative period (bolus and infusion doses divided by the elapsed time from the first bolus to the end of infusion, ìg/kg/min).