Skip to main content
. 2019 Jul 4;30(2):753–766. doi: 10.1093/cercor/bhz123

Figure 7.

Figure 7

Cx30 GJ channels do not contribute to the activity-dependent increase in glucose trafficking within astroglial networks. (A) Sample images of functional coupling between CA1 astrocytes visualized by diffusion of 2-NBDG (green) via patch-clamp whole-cell recording for 20 min, together with dextran tetramethylrhodamine (red) to identify the recorded astrocyte. The upregulation of 2-NBDG interastrocytic trafficking induced by 0Mg-P (100 μM, 3 h) is independent of Cx30 GJ channels as it is unchanged in Cx30−/− mice. Scale bar, 100 μm. (B) Graph summarizing the extent of 2-NBDG astrocytic coupling during spontaneous and neuronal bursting conditions (+/+: Control (Ct): n = 21, 0Mg-P: n = 15; −/−: Ct: n = 11, 0Mg-P: n = 6). Asterisks indicate statistical significance (*P < 0.05).