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. 2020 Feb 7;19(4):2449–2456. doi: 10.3892/etm.2020.8498

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Copyright: © Jiang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Analysis of the association among β-lactamase, PBPs and zinc finger nuclease in PD-K.p (A) mRNA expression levels of PBP and β-lactamase were analyzed in PD-K.p (B) PBP knockdown suppressed the inhibitory effects of zinc finger nuclease on PD-K.p growth. (C) Zinc finger nuclease was superior to PBP in inhibiting PD-K.p growth. (D) Zinc finger nuclease inhibited BlaR1 and Blal expression in the β-lactamase signaling pathway in PD-K.p (E) Fluorescence microscopic detection of the action site of zinc finger nuclease in PD-K.p (F) Upper panel shows the analysis of the immunoprecipitation of zinc finger nuclease (ZFN) in PD-K.p cells with antibody-conjugated magnetic nanoparticles (MNPs). Data are presented as the mean ± SEM. ^**P<0.01, statistically significant difference. NB-K.p, natural being Klebsiella pneumoniae; PD-K.p, Klebsiella pneumoniae from a patient with pneumonia; PBPs, penicillin-binding proteins.