Fig. 7.

HON sensory responses are state dependent.

A, Recording schedule for comparing sensory responses in hungry and re-fed animals. B, Example responses to food odor from six cells in hungry (gray) and re-fed (black) conditions. C, likelihood of initiating a locomotion bout following sensory stimulus across all four mice. D, Mean responses from trials where mice remained stationary, measured from an analysis window 1–4 s after sensory stimulus onset, colour coded by cell type as shown in legend. Overall mean responses in black (hungry response ± s.e.m., re-fed response ± s.e.m., P-value: visual 0.093 ± 0.014, 0.101 ± 0.015, P = 0.49; tactile 0.054 ± 0.012, 0.079 ± 0.016, P = 0.03; food odor 0.291 ± 0.032, 0.181 ± 0.023, P = 10⁻⁸; social odor 0.233 ± 0.033, 0.174 ± 0.022, P = 0.003). E, Responses to food odor from D by cell type according to legend in D (mean ± s.e.m. values in black: ON 0.34 ± 0.04, 0.24 ± 0.04; OFF 0.15 ± 0.08, 0.08 ± 0.04; up-down 0.32 ± 0.07, 0.21 ± 0.06; down-up 0.18 ± 0.04, 0.06 ± 0.05). F, Responses to social odor from D by cell type according to legend in D (mean ± s.e.m. values in black: ON 0.28 ± 0.04, 0.21 ± 0.04; OFF 0.012 ± 0.07, 0.06 ± 0.04; up-down 0.32 ± 0.10, 0.17 ± 0.06; down-up 0.04 ± 0.02, 0.11 ± 0.03). In D–F, n.s. P > 0.0125, * P < 0.0125, ** P < 0.001, *** P < 10⁻⁷.