Table 3.
Cox Proportional hazards regression model for overall death in the years 2001-2011 compared with 1990-2000 in women with adenocarcinoma of the breast stratified by single variables of race, age grouping, stage, ER status, PR status, marital status and laterality and by race and stage.
| Variables | Cox Hazard Ratio (Confidence Intervals) | P (Pearson Chi Square) | P (Scaled Schoenfeld residuals test) | Number of patients (1990-2000/ 2001-2011) |
|---|---|---|---|---|
| Caucasians | ||||
| All stages | 0.76 (0.74 - 0.77) | < .001 | < .001 | 87,453/266,625 |
| Stage I | 0.78 (0.75 - 0.81) | < .001 | 0.525 | 42,854/131,815 |
| Stage II | 0.70 (0.67 - 0.72) | < .001 | 0.023 | 29,922/ 92,324 |
| Stage III | 0.74 (0.71 - 0.77) | < .001 | 0.030 | 12,171/ 31,558 |
| Stage IV | 0.72 (0.68 - 0.76) | < .001 | 0.501 | 2,506/ 10,928 |
| African Americans | ||||
| All stages | 0.76 (0.72 - 0.80) | < .001 | 0.028 | 8,075/ 33,017 |
| Stage I | 0.71 (0.63 - 0.81) | < .001 | 0.852 | 2,744/11,812 |
| Stage II | 0.73 (0.67 - 0.79) | < .001 | 0.892 | 3,286/13,163 |
| Stage III | 0.70 (0.64 - 0.76) | < .001 | 0.478 | 1,660/ 5,743 |
| Stage IV | 0.75 (0.66 - 0.86) | < .001 | 0.046 | 385/ 2,299 |
| Age grouping - all patients | ||||
| < 40 | 0.70 (0.65 - 0.76) | < .001 | 0.566 | 6,509/ 17,864 |
| 40-69 | 0.72 (0.70 - 0.74) | < .001 | < .001 | 61,512/205,977 |
| ≥ 70 | 0.91 (0.88 - 0.93) | < .001 | < .001 | 27,507/ 75,801 |
| Grade - all patients | ||||
| 1 | 0.80 (0.75 - 0.85) | < .001 | 0.502 | 14,676/ 58,478 |
| 2 | 0.81 (0.78 - 0.83) | < .001 | < .001 | 42,043/126,992 |
| 3 | 0.79 (0.77 - 0.81) | < .001 | < .001 | 38,809/114,172 |
| ER status - all patients | ||||
| + | 0.74 (0.73 - 0.76) | < .001 | 0.002 | 73,138/235,166 |
| - | 0.86 (0.83 - 0.89) | < .001 | < .001 | 22,390/ 64,476 |
| PR status - all patients | ||||
| + | 0.74 (0.72 - 0.76) | < .001 | 0.015 | 64,201/202,903 |
| - | 0.81 (0.78 - 0.83) | < .001 | < .001 | 31,327/ 96,739 |
| Marital status - all patients | ||||
| Single | 0.81 (0.76 - 0.85) | < .001 | 0.013 | 10,848/ 41,472 |
| Married | 0.71 (0.69 - 0.73) | < .001 | 0.166 | 56,195/175,415 |
| Separated | 0.85 (0.69 - 1.04) | 0.120 | 0.024 | 611/ 3,178 |
| Divorced | 0.84 (0.79 - 0.89) | < .001 | 0.058 | 9,893/ 34,003 |
| Widowed | 0.92 (0.89 - 0.95) | < .001 | 0.002 | 17,981/ 45,574 |
| Laterality - all patients | ||||
| Right | 0.77 (0.75 - 0.79) | < .001 | < .001 | 46,833/147,824 |
| Left | 0.77 (0.75 - 0.79) | < .001 | < .001 | 48,695/151,818 |