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. 2020 Feb 20;11(10):2759–2768. doi: 10.7150/jca.37718

Figure 4.

Figure 4

CircCCDC66 gene silencing suppresses while gene overexpression promotes the apoptosis of GC cells. (A) Flow cytometric analyses of cell apoptosis in control and circCCDC66 knockdown groups. (B) QRT-PCR analyses of Bcl-2 and Bax gene expression in circCCDC66 knockdown and overexpressing GC cells. (C) Western blot analyses of p21, poly (ADP- ribose) polymerase (PARP), Bcl-2 and Caspase-3 expression in circCCDC66 knockdown and overexpressing GC cells. All the experiments were repeated for three times. *P <0.05, **P <0.01, ***P <0.001.