Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 10;19(4):2527–2534. doi: 10.3892/etm.2020.8504

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Cai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 4. — miR-449b-3p suppresses EMT through the IL-6/JAK2/STAT3 pathway. (A) IL-6 mRNA expression in A549 transfected with IL-6. Data were analyzed using Student's t-tests. (B) Western blotting and (C) quantification showing the activation of JAK2, and STAT3, through the phosphorylation of these proteins, as well as the suppression of EMT markers, by miR-449b-3p. This observation was reversed by IL-6 restoration. Analyzed using one-way ANOVA with Tukey's post-hoc comparisons. ^*P<0.05, ^**P<0.01. EMT, epithelial-mesenchymal transition; IL, interleukin; JAK, Janus kinase; miR, microRNA; NC, negative control.