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Clinical course. After the administration of LEN, the serum CRP levels suddenly increased. The first gallbladder perforation developed. After resuming LEN, the serum CRP levels increased and the gallbladder perforation was reproduced. SOR: sorafenib, AMI: acute myocardial infarction, REG: regorafenib, LEN: lenvatinib, CRP: C-reactive protein, CT: computed tomography
