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. 2020 Mar 4;10(9):3967–3979. doi: 10.7150/thno.40566

Figure 5.

Figure 5

TRAF6 mediates the effect of miR-146a-5p on GEM resistance in PDAC cells. (A-D) qPCR and Western blotting analyses confirmed TRAF6 knockdown and overexpression in PANC-1 and SW1990 cells. (E-F) The IC50 values of GEM in PANC-1 and SW1990 cells transfected with the TRAF6-specific shRNA or TRAF6 overexpression vector (*P < 0.05, **P < 0.01). (G-H) The apoptosis rate of PANC-1 and SW1990 cells transfected with TRAF6 shRNA or overexpression vector and treated with GEM (10 µM, 48 h) was measured (*P < 0.05, **P < 0.01). (I-J) Comparison of the IC50 values of GEM in PANC-1 and SW1990 cells treated with miR-146a-5p mimics/inhibitor either alone or in conjunction with transfection of the TRAF6-overexpressing vector (*P < 0.05, **P < 0.01).