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. 2020 Mar 4;10(9):4233–4249. doi: 10.7150/thno.40664

Figure 3.

Figure 3

Impaired insulin secretory response to glucose challenge in Egr1-/- mice after HF feeding. A: Expression of genes for glucose sensing and secretion coupling in isolated islets of 5-month-old male mice fed RC (upper panel) and a HF diet (lower panel) for 3 months. B: In vivo glucose-stimulated insulin secretion (GSIS) and C: arginine-stimulated insulin secretion (ASIS) in 4-month-old male mice fed RC (upper panel) or a HF diet (lower panel) for 2 months after intraperitoneal challenge of glucose (3 g/kg body weight) and arginine (0.3 g/kg body weight), respectively. D: Ex vivo GSIS in isolated pancreatic islets from male mice fed RC (upper panel) or a HF diet (lower panel). Numbers of mice are inside bars. *P<0.05 and **P<0.01.