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. 2020 Mar 4;10(9):4088–4100. doi: 10.7150/thno.42416

Figure 2.

Figure 2

IL-37 expression was positively correlated with Gem efficacy and negatively correlated with HIF-1α expression in PDAC. (A) Representative images for immunohistochemical IL-37 staining in Gem-resist and sensitive PDAC patients. (B) Association of IL-37 expression with RFS rate in PDAC patients with Gem treatment (n=76, P = 0.035). (C) Western blot analysis of IL-37 expression in SW1990 and PANC-1 cells treated with the Gem (2 µM) for 48 h. (D) and (E) IHC assay of the expression of HIF-1α and IL-37 in human PDAC samples (n = 85, P = 0.026). (F) Western blot analysis of IL-37 and HIF-1α expression in Gem-resistance cells (FG and BxPC-3).