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. 2020 Mar 4;10(9):3892–3904. doi: 10.7150/thno.41850

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In vivo cytokine profiling and immunosuppression. Schematic of the lipopolysaccharide (LPS)/cecum ligation and puncture (CLP) model treated with mycophenolic acid (MPA), oxygen nanobubbles (ONBs), or ONB/MPA (upper). (A) Animal survival after LPS (30 mg/kg, administered intraperitoneally)-induced sepsis (n=15 mice per group). (B) Animal survival after CLP procedure (n=15 mice per group). The data are representative of two independent experiments with similar results. (C) Serum cytokine levels (TNF-α and IL-6) and (D) inflammation score in the lung and liver, obtained by hematoxylin and eosin staining. These were determined at 30 h in CLP mice treated with MPA, ONBs, or ONB/MPA (n=15 mice per group). Significant differences (*p < 0.01; ***p < 0.001) compared with CLP only. Gray bar indicates sham.