Figure 1.

REV‑ERBα in circadian clock system. (A) Schematic diagram for molecular clock machinery. Mammalian molecular clock consists of three interlocked auto-regulatory feedback loops. The three loops are attained through PERs/CRYs (black lines), REV-ERBs/RORs (green lines) and DBP/E4BP4 (blue lines), respectively. (B) Circadian mRNA expression patterns of clock genes in mice. (C) General patterns for regulation of target genes by REV‑ERBα. REV‑ERBα directly regulates transcription of target genes via single RORE (i), RevDR2 (ii) or two adjacent ROREs (iii), and indirectly regulates gene transcription via other transcription factors (TFs) (iv).