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REV‑ERBα regulates immune genes in macrophages and TH17 cells. (A) In macrophages, a variety of immune genes (i.e., P65, Nlrp3, IL-1β, TLR4, IL-6, Ccl2, Mmp9 and Cx3cr1) are controlled by REV-ERBα. (B) REV-ERBα negatively regulates TH17 cell development by competing with RORgt at the RORE of Il-17a. An additional mechanism involves REV-ERBα-mediated repression of RORgt.
