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. 2020 Mar 4;10(9):4168–4182. doi: 10.7150/thno.43834

Table 2.

Phenotypes of REV-ERBα ablation and the underlying mechanisms

Tissues Phenotypes Mechanisms Refs
Liver Fulminant hepatitis, IL-1β and IL-18 secretion NLRP3 inflammasome, Transcription of Nlrp3 and IL-1β 27
Liver Diabetes Transcription of PCK and G6Pase 6, 57-61
Liver Hyperlipidemia Transcription of ApoC-III and Elovl3 6,69,70,72
Liver Hypercholesterolemia Expression of HMGCR and CYP7A1 71,74-76
Liver Hyperhomocysteinemia Transcription of Bhmt, Cbs, Cth and C/EBPα 80
Lung Pulmonary inflammation Expression of chemokines and inflammatory cytokines 40
Lung Pulmonary fibrosis TBPL1-integrinβ1 pathway 56
Colon Ulcerative colitis NF-κB signaling pathway, NLRP3 inflammasome, Transcription of Nlrp3 25
Heart Ischaemia-reperfusion injury, Immunocyte recruitment NLRP3 inflammasome 36
Heart Perioperative myocardial injury Expression of CDKN1a/p21. 30
Bone Osteoporosis, Osteoclastogenesis Expression of FABP4 84
Bone Osteogenesis Expression of bone sialoprotein 85
Pancreas Glucose-induced insulin secretion in β-cells, Glucagon secretion in α-cells Exocytotic process, AMPK/Nampt/Sirt1 pathway 62-64