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. 2016 Mar 31;2016(3):CD011390. doi: 10.1002/14651858.CD011390.pub2

Valenti 2008.

Methods Study design: prospective cohort study
Participants Country: UK.
 Number eligible: 40.
 Number excluded: 0 (0%).
 Number analysed: 40.
 Average age: 67 years.
 Females: 8 (20%).
 Stage I: not stated
 Stage II: not stated
 Stage III: not stated
 Stage IV: not stated
 Squamous cell carcinoma: 9 (22.5%).
 Adenocarcinoma: 28 (70%).
 Study design: Prospective cohort study with contemporary controls
 Total follow‐up in months: not stated
 ASA: ASA I or II: 12 versus 17; ASA III or IV: 4 versus 7
 Location: lower third
Inclusion criteria
 Patients undergoing transhiatal oesophagectomy for oesophageal cancer
Interventions Group 1: laparoscopic transhiatal oesophagectomy (N = 16).
 Further details: number of ports ‐ 5; minilaparotomy ‐ 7 cm incision; drain use ‐ not stated.
 Group 2: open transhiatal oesophagectomy (N = 24).
 Further details: incision size ‐ not stated; drain used‐ not stated.
Outcomes The outcomes reported were short‐term mortality and number of lymph nodes harvested.
Notes Proportion of people with cancer: 93% (remaining patients had high grade dysplasia)
Conversion: 0/16 (0%)
Risk of bias
Bias Authors' judgement Support for judgement
Bias due to confounding Unclear risk No information
Comment: There was no evidence of baseline differences between the groups. However, the sample size was not sufficient to identify baseline differences. In addition, not all confounding factors were listed in the baseline differences table (for example, no information was presented on the differences in the stage of the tumours)
Bias due to selection of participants to intervention and control Unclear risk No information
Comment: Method of selection of participants to intervention and control was based on surgeon's preference.
Bias due to differences in co‐interventions which were different between the groups Unclear risk No information
Comment: It was not clear there were other differences in care of the patient apart from the intervention and control.
Bias in the measurement of outcomes High risk High risk of bias
Quote: "No blinded assessors (author replies)".
Bias due to missing data Low risk Low risk of bias
Quote: "No patients excluded from analysis (author replies)".
Bias in selection of the reported findings High risk Serious risk of bias
Comment: Morbidity was not reported.