Table 1.
Clinical Characteristics of the Study Sample
| Characteristic | Entire cohort (N=553) | Apolipoprotein ε4 status |
|
|---|---|---|---|
| ε4 (N=106) | No ε4 (N=447) | ||
| Age, M ± SD | 76.7 ± 5.2 | 75.8 ± 4.3 | 77.0 ± 5.3 |
| Female, n (%) | 324 (58) | 63 (58) | 261 (58) |
| Surgery type, n (%) | |||
| Orthopedic | 451 (81) | 81 (75) | 370 (83) |
| Vascular | 35 (6) | 7 (6) | 28 (6) |
| Colectomy | 71 (13) | 20 (19) | 51 (11) |
| Preoperative GCP*, M ± SD | 57.6 ± 7.3 | 57.6 ± 7.9 | 57.6 ± 7.1 |
| CRP postop day 2**, M ± SD | 181.9 ± 81.2 | 167.5 ± 85.7 | 185.3 ± 79.8 |
| Major postop complication, n (%) | 47 (8) | 8 (7) | 39 (9) |
| Delirium incidence, n (%) | 132 (24) | 26 (25) | 106 (24) |
| Delirium severity***, M ± SD | 9.3 ± 11.4 | 9.0 ± 11.2 | 9.3 ± 11.5 |
| Delirium days, n (%) | |||
| 0 | 421 (76) | 80 (75) | 341 (76) |
| 1 | 82 (15) | 17 (16) | 65 (14) |
| 2 | 28 (5) | 6 (6) | 22 (5) |
| 3+ | 22 (4) | 3 (3) | 19 (5) |
abbreviations: CRP=C-reactive protein, GCP =general cognitive performance, M=mean, SD=standard deviation
Apolipoprotein E ε4 carriers defined as ε4ε4 and ε4ε3.
*
Composite measure of neuropsychological measures reflecting cognitive domains vulnerable to delirium, population mean 50 ± 10, externally scaled to the Health and Retirement Survey of Aging, Demographics, and Memory Study [61]
**
See Supplementary Figure 2 for distribution of CRP measured preoperatively and on POD2 by Apolipoprotein E ε4 carrier status
***
Defined as the sum of Confusion Assessment Method (CAM)-S scores, which sums the severity ratings of 10 CAM features (range 0-19, 19 most severe).