Table 2.
The genotype frequency of four significant loci between ITP patients and controls.
| SNP | Closest genes | Chr | Position | P value in pooling GWAS | Risk allele | Genotypes | Genotype frequency | χ 2 | OR (95% CI) | P | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases n (%) | Controls n (%) | ||||||||||
| rs117503120 | GBE1/LINC02027 | 3 | 81352557 | 6.45 × 10−9 | G | GG | 235 (94.0) | 215 (86.0) | 7.28 | 0.43 (0.27–0.67) | 0.026 |
| GA | 15 (6.0) | 35 (14.0) | |||||||||
| AA | 0 (0.0) | 0 (0.0) | |||||||||
|
| |||||||||||
| rs4483616 | TENM4 | 11 | 78824323 | 8.84 × 10−9 | / | / | / | / | / | / | / |
| / | / | / | / | / | / | / | |||||
| / | / | / | / | / | / | / | |||||
|
| |||||||||||
| rs5998634 | TIMP3/SYN3 | 22 | 33169115 | 8.06 × 10−8 | T | CC | 212 (84.8) | 238 (95.2) | 12.5 | 3.19 (1.98–5.16) | 0.0019 |
| CT | 36 (14.4) | 12 (4.8) | |||||||||
| TT | 2 (0.8) | 0 (0.0) | |||||||||
|
| |||||||||||
| rs16866133 | RBM45/OSBPL6 | 2 | 179022610 | 9.39 × 10−8 | T | TT | 247 (99.5) | 235 (94.0) | 7.73 | 0.20 (0.08–0.49) | 0.03 |
| TG | 3 (0.5) | 15 (6.0) | |||||||||
| GG | 0 (0.0) | 0 (0.0) | |||||||||
SNP, single nucleotide polymorphism; Chr, chromosome; ITP, primary immune thrombocytopenic; CI, confidence interval; the positions are based on the GRCh37 assembly. The significance threshold is P value <1.0 × 10−7.