Table 4.
The overrepresentation pathways identified by the top 287 genes with a P value <1.0 × 10−5 in this pooling GWAS.
| Pathway name | Total | Observed | E-ratio | P | Adj-P |
|---|---|---|---|---|---|
| JAK-STAT signaling pathway | 155 | 6 | 6.27 | 0.0004 | 0.0054 |
| Neuroactive ligand-receptor interaction | 256 | 8 | 5.06 | 0.0002 | 0.0054 |
| Pathways in cancer | 330 | 8 | 3.93 | 0.0011 | 0.0099 |
The number of reference genes in the category (total); ratio of enrichment (E-ratio); P value from hypergeometric test; P value adjusted by the multiple test adjustment (Adj-P), the significant threshold of Adj-P is P < 1.0 × 10−5.