Table 2.

Covariates collected at baseline and throughout follow-up.

Variable	Categorization of covariate	Baselin e	Time-Varying
Clinical & Participant Data
Etiology of liver disease	HCV, HBV, EtOH, NASH, PBC, PSC, AIH, hemochromatosis, Wilson’s, other	X
Family history of liver disease	HCV, HBV, EtOH, NASH, PBC, PSC, AIH, hemochromatosis, Wilson’s, other	X
Race	White, Black, Asian, other	X
Ethnicity	Hispanic/Latino yes/no	X
Sex	Male, Female	X
Age	Continuous	X	X
Body mass index	Continuous	X	X
Physical performance status	Fully active, ambulatory but unable to work, restricted to chair/bed	X	X
Ascites	Binary yes/no	X	X
Hepatic encephalopathy	Binary yes/no	X	X
Varices	Binary yes/no	X	X
Hepatorenal syndrome	Binary yes/no	X	X
HCV status	No HCV, HCV with viremia, HCV with SVR	X	X
HCV antiviral use	(LIST)	X	X
Statin use (current, previous)	Atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin	X	X
Metformin use (current, previous)	Binary yes/no	X	X
# Children, # Siblings	Continuous	X	X
Smoking (current, previous)	Continuous	X	X
Alcohol (current, previous)	Continuous	X	X
Coffee and tea consumption	Amount per day/week/month	X	X
Personal and immediate family cancer history & diagnosis	Bladder, brain, cervix, esophagus, kidney, leukemia, lymphoma, pancreas, rectum, stomach, bone, breast, colon, head/neck, liver, lung, ovary, prostate, melanoma, thyroid	X	X
Laboratory Data
Chemistry: ALT, AST, ALP, albumin, bilirubin, creatinine, sodium	Continuous	X	X
Hematology: Hct, Hgb, WBC, Plts	Continuous	X	X
INR	Continuous	X	X
AFP	Continuous	X	X

Abbreviations: HCV=hepatitis C virus; NASH=non-alcoholic steatohepatitis; HBV=hepatitis B virus; PBC=primary biliary cirrhosis; PSC=primary sclerosing cholangitis; AIH=autoimmune hepatitis; AST=aspartate aminotransferase; ALT=alanine aminotransferase; ALP=alkaline phosphatase; Hct=hematocrit; Hbg=hemoglobin; WBC=white blood cells; Plts=platelets; INR=international normalized ratio