Table 2.
Frequencies of IL28B rs12979860 and rs8099917 SNP in infants hospitalized for global and RSV-bronchiolitis
| Recessive model | Birth weight (g) | Age at hospital admission, (months) | Weight at hospital admission (g) | Hospital length of stay, (days) | PICU length of stay, (days) | Supplemental oxygen days (days) | Highest oxygen requirement (FiO2) | |
|---|---|---|---|---|---|---|---|---|
| Global bronchiolitis (N = 682) | IL28B rs12979860 | |||||||
| TT | 3349.5 (495.4) | 7.69 (2.81) | 7.93 (2.74) | 5.69 (3.53) | 1.05 (2.26) | 4.65 (3.74) | 0.3 (0.1) | |
| CC+CT | 3363.1 (479) | 8.61 (3.46) | 8.63 (3.1) | 6.17 (4.8) | 1.26 (2.97) | 5.02 (4.72) | 0.32 (0.13) | |
| p value | 0.78 | 0.021* | 0.046* | 0.31 | 0.48 | 0.42 | 0.12 | |
| IL28B rs8099917 | ||||||||
| GG | 3274.1 (450.55) | 7.57 (6.28) | 7.62 (2.5) | 5.64 (3.4) | 0.9 (2.14) | 4.63 (3.34) | 0.31 (0.11) | |
| CG+CC | 3370.3 (484.2) | 9.37 (7.2) | 8.61 (3.47) | 6.14 (4.73) | 1.26 (2.93) | 5 (4.65) | 0.32 (0.13) | |
| p value | 0.12 | 0.049* | 0.023* | 0.4 | 0.32 | 0.52 | 0.33 | |
| RSV bronchiolitis (N = 464) | IL28B rs12979860 | |||||||
| TT | 3314.3 (503) | 7.76 (6.84) | 7.66 (2.75) | 5.99 (3.5) | 1.18 (2.43) | 4.89 (3.5) | 0.3 (0.09) | |
| CC+CT | 3369.5 (490.7) | 8.79 (7.1) | 8.24 (3.36) | 46.4 (4.97) | 1.38 (3.1) | 5.35 (4.8) | 0.33 (0.14) | |
| p value | 0.36 | 0.22 | 0.1 | 0.4 | 0.6 | 0.41 | 0.037* | |
| IL28B rs8099917 | ||||||||
| GG | 3262.6 (437.5) | 7.2 (6.4) | 7.52 (2.6) | 5.48 (3.1) | 0.69 (2.05) | 4.43 (3.1) | 0.28 (0.07) | |
| CG+CC | 3372.4 (498.2) | 8.8 (7.1) | 8.22 (3.34) | 6.46 (4.9) | 1.42 (3.1) | 5.37 (4.48) | 0.32 (0.13) | |
| p value | 0.12 | 0.11 | 0.13 | 0.047* | 0.02* | 0.15 | <0.001* | |
*Significant