viral infections	bacterial infections	end organ damage immune dysregulation	immunology
mother	mumps and varicella disease (despite immunization), recurrent HSV1 infections (face, index finger)	tracheobronchitis (H. influenza) P. jirovecii pneumonia	bronchiectases, COPD, loss of distal phalanx (Dig.II) following HSV infection, ulceration of vocal chords, hypopituitarism, vasculitis of lower legs	IgG 3.44 g/l, IgA < 0.26 g/l, IgM 0.45 g/l, no protective tetanus and diphtheria antibodies following regular immunization, absence of autoantibodies, initally low switched memory B- cells, total loss of peripheral B-cells
daughter	recurrent upper and lower respiratory infections, recurrent HSV1 infections periorally		mild restrictive lung disease, alopecia totalis, nail dystrophy	IgG 2.33 g/l, IgA 0.23 g/l, IgM 0.34 g/l, B-cells 1900/μl, no protective tetanus, measles or HiB antibodies (but positive to rubella)