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Inhibitory effects of viroporin inhibitors against FIPV
| Compound | CC50 (μM) | FIPV type I strain KU2 | FIPV type I strain Black | FIPV type II strain 79-1146 | |||
|---|---|---|---|---|---|---|---|
| EC50 (μM) | SI | EC50 (μM) | SI | EC50 (μM) | SI | ||
| 4,4′-disothiocyano-2,2′-stilbenedisulphonic acid (DIDS) | 318.7 ± 22.0 | 185.0 ± 17.1 | 2.9 ± 0.3 | 207.8 ± 10.0 | 2.2 ± 0.1 | 69.6 ± 6.9 | 6.1 ± 1.0 |
| Amantadine | 2230.9 ± 178.0 | >1000 | <2 | >1000 | <2 | >1000 | <2 |
| Hexamethylene amiloride (HMA) | 48.8 ± 1.9 | 1.9 ± 0.8 | 25.5 ± 2.2 | 2.1 ± 0.2 | 23.3 ± 2.2 | 10.3 ± 0.1 | 4.9 ± 0.1 |
