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. 1984;80(4):333–347. doi: 10.1007/BF01311223

Protein synthesis in cells infected by murine hepatitis viruses JHM and A59: Tryptic peptide analysis

C W Bond 1,2, K Anderson 1, J L Leibowitz 3
PMCID: PMC7086976  PMID: 6329143

Summary

The structural and intracellular proteins of the murine hepatitis viruses MHV-JHM and MHV-A59 were studied by tryptic peptide mapping. The results demonstrated that the virions contained three distinct proteins: the two related chains of the E2 complex, the nucleocapsid protein and the heterogeneous E1 complex. Five distinct virus-specific proteins were synthesized by infected cells. Three of the five intracellular proteins contained tryptic-peptides with properties similar to the three structural proteins. Models describing the evolution of the proteins are proposed. Although the pathogenic properties of MHV-JHM and MHV-A59 differ greatly, the tryptic peptide maps of the corresponding proteins of these MHV strains were remarkably similar.

Keywords: Peptide, Hepatitis, Infectious Disease, Protein Synthesis, Infected Cell

Footnotes

With 8 Figures

References

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