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. 2008 Nov 7;153(12):2189. doi: 10.1007/s00705-008-0243-2

Table 4.

Amino acid variations in natural isolates

Amino acid position Changed amino acids Surface (S) or inside (I)
20 A, I, T S
22 N, S, T S
45 D, G, N S
48 H, P, R S
53 D, K, N S
69 I, P, Q S
94 I, N, T S
103 A, L, S, T I
131a K, R, S S
135b D, G, N S
146 E, H, K, Q S
148a D, N, S S
150 A, D, S, T S
153 I, T, V S
164 E, K, R S
179b A, N, T S
180 A, E, G, T, V S
182a D, E, N S
200 D, N, T S
206 L, M, S, V S
216b L, M, Q S
264 H, K, N, T, Y S
265 G, K, N, R, S S
267 D, N, S S
269 A, T, V I
316 A, S, T Cleavage site
317 G, K, R Cleavage site
318 A, L, S Cleavage site

Amino acid comparison was performed with 133 viruses clustered with Y280 lineage, isolated from 1994 to 2005. Positions were selected in which three or more amino acids were different. Escape mutant has a change in this residue in this study (a) and in that of Kaverin et al. (b) [12]