Table 5.
Comparison of functional motifs in the spike (S), envelope (E) and membrane (M) proteins
| S | E | M | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Proteolytic cleavage site | ER retention signal | Variable amino acid residue in ectodomain | ||||||||
| S1/S2 | S2’(fusion peptide) | 5 | 6 | 11 | 12 | 13 | 16 | 17 | ||
| KM91 | 534RRFRR/Sa539 | 688 PSGR/Sa692 | 103RHGKLHSb109 | G | E | S | T | Q | A | E |
| QIA-03342 | 536HRRRR/S541 | 690 PSGR/S694 | -c | - | N | - | E | V | Q | |
| QIA-KR/D79/05 | D | - | - | - | - | - | - | |||
| QIA-Q43/06 | 534RRFRR/Sa539 | 688 PRRR/Sa692 | - | - | N | - | E | V | Q | |
| SNU9106 | 536RRFRR/S541 | 690 PSGR/S694 | - | - | - | - | - | - | - | |
| SNU10043 | - | - | - | - | - | - | - | |||
| YX10 | 536HRRRR/S541 | 690 PRGR/S694 | 103RDKLHP108 | E | .d | D | S | E | I | L |
| SNU8065 | E | . | D | S | E | I | L | |||
| SNU11045 | E | . | D | S | E | I | L | |||
aThe different location numbers of KM91 and QIA-Q43/06 are due to the 24G and 25N deletion
bThe different location number is due to an insertion at 105G
cSame amino acid sequence as KM91
dNon-comparable amino acid residue due to 6E insertion