Fig. 6.

NoV capsid-specific antibody responses of BALB/c mice immunized twice intradermally (ID) with 1 μg or 10 μg of pure NoV GII-4 VLPs. (A) Serum samples collected at study weeks 0 (pre-bleed), 2, 3, 4 and 5 were tested by ELISA for NoV-specific IgG. The arrows indicate immunization points at study weeks 0 and 3. NoV-specific serum IgG1 (B) and IgG2a (C) subtype antibody responses. Mean ODs of the groups with standard errors are shown. Control mice were left unvaccinated