Table 1.

Structural and nonstructural proteins of dengue virus

Protein	Size	Subunits	Functions	References
C	100 amino acids	None	Facilitates capsid assembly	[11]
prM/M	21 kDa/8 kDa	None	prM interacts with and stabilizes the E protein.	[12]
E	53 kDa	None	Forms outer protein envelope Receptor-binding capability	[12, 13]
NS1	48 kDa	None	Cleaves the NS1–NS2A junction Involved in the early steps of viral replication	[14–16]
NS2	22 kDa	NS2A, NS2B	NS2A plays a role in RNA synthesis and virion maturation and as an activator of correct NS1 processing NS2B acts as an activator of NS3, allowing its proper function	[7, 17]
NS3	618 amino acids	None	Acts as a protease when combined with NS2B Functions as an RNA helicase and RTPase/NTPase	[18, 19]
NS4	16 kDa	NS4A, NS4B	Plays a role in membrane curvature and facilitates protein–protein interactions	[20–22]
NS5	104 kDa	None	Essential for the replication and transcription of the viral genome	[23, 24]