Table 1.
Protein | Size | Subunits | Functions | References |
---|---|---|---|---|
C | 100 amino acids | None | Facilitates capsid assembly | [11] |
prM/M | 21 kDa/8 kDa | None | prM interacts with and stabilizes the E protein. | [12] |
E | 53 kDa | None |
Forms outer protein envelope Receptor-binding capability |
[12, 13] |
NS1 | 48 kDa | None |
Cleaves the NS1–NS2A junction Involved in the early steps of viral replication |
[14–16] |
NS2 | 22 kDa | NS2A, NS2B |
NS2A plays a role in RNA synthesis and virion maturation and as an activator of correct NS1 processing NS2B acts as an activator of NS3, allowing its proper function |
[7, 17] |
NS3 | 618 amino acids | None |
Acts as a protease when combined with NS2B Functions as an RNA helicase and RTPase/NTPase |
[18, 19] |
NS4 | 16 kDa | NS4A, NS4B | Plays a role in membrane curvature and facilitates protein–protein interactions | [20–22] |
NS5 | 104 kDa | None | Essential for the replication and transcription of the viral genome | [23, 24] |