Fig. 5.

Amino acid sequence alignment. Comparisons were done between the Mebus strain and the Uruguayan strains, and also between the two lineages circulating in Uruguay. Accession numbers of Uruguayan strains related to Argentinian and Brazilian strains are shown in red and green, respectively. The Mebus strain sequence was used as a reference. Numbers above the amino acid sequence indicate the position of the complete spike sequence of strain Mebus (accession number: U00735). Dots indicate conserved positions, and amino acid changes are represented using the corresponding one-letter symbol. Positions with more than 80% of strains containing differences are indicated by squares. Red, 100% of Uruguayan strains different from Mebus; orange, > 75% of Uruguayan strains different from Mebus; pink, > 50% of Uruguayan strains different from Mebus; dark blue, 100% of strains with differences between lineages; in light blue, > 50% of strains with differences between lineages, black, and other changes