Table 2.
Top 8 independent SNPs in the meta-analysis of the discovery samples (present in at least one replication sample). SNPs are displayed when not in linkage disequilibrium (R2<0.1. For SNPs with R2 >= 0.1 only the most significant SNP is shown in the top 8).
| SNP | Chr | BP (hg19) | A1 | A2 | Freq A1 | beta (s.e.) | P | Direction* |
|---|---|---|---|---|---|---|---|---|
| rs1574587 | 16 | 84453056 | T | C | 0.1415 | 0.09 (0.016) | 4.0×10−9 | +?+++++−+ |
| rs4935127 | 10 | 56654986 | C | G | 0.7741 | −0.06 (0.013) | 4.6×10−7 | −−−+−−−+− |
| rs2249437 | 6 | 1595216 | T | C | 0.4595 | 0.07 (0.014) | 5.1×10−7 | ++++?+?++ |
| rs9266245 | 6 | 31325702 | A | G | 0.2655 | −0.07 (0.015) | 1.6×10−6 | −−−−?−−?− |
| rs28622199 | 8 | 5392103 | T | C | 0.8012 | 0.07 (0.015) | 2.7×10−6 | +++−+++++ |
| rs215069 | 16 | 16091237 | T | C | 0.0685 | −0.11 (0.025) | 3.8×10−6 | −?−?−−??− |
| rs4924506 | 15 | 41129467 | A | C | 0.7318 | 0.06 (0.013) | 5.5×10−6 | ++++++−−+ |
| rs7773177 | 6 | 139143088 | A | G | 0.7383 | −0.06 (0.013) | 8.5×10−6 | −−−−−−−+− |
Direction per sample: allele A1 increases (+) or decreases (−) liability for cannabis use, or sample did not contribute to this SNP because it did not pass the post-imputation quality control (?). Only SNPs present in at least 2 samples were included in the meta-analysis. Order of samples in the discovery: ALSPAC, BLTS, FinnTwin, HUVH, NTR, QIMR, TRAILS, Utrecht, Yale Penn EA. Sample information can be found in Table 1.
Chr = Chromosome; BP (hg19) = location in base pairs in human genome version 19, A1 = allele 1, A2 = allele 2, Freq A1 = Frequency of allele 1, s.e. = standard error, P = p-value.