Table 1.
Arterial pH, blood gases, glucose, and lactate values
| Baseline | Before bolus 1 | Bolus 1 + 2 h | Bolus 1 + 6 h | Before bolus 2 | Bolus 2 + 2 h | Bolus 2 + 6 h | Before bolus 3 | Bolus 3 + 2 h | Bolus 3 + 6 h | Recovery | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| pH | Saline | 7.33 ± 0.01 | 7.33 ± 0.01 | 7.34 ± 0.01 | 7.33 ± 0.01 | 7.33 ± 0.01 | 7.33 ± 0.01 | 7.33 ± 0.01 | 7.32 ± 0.01 | 7.33 ± 0.01 | 7.32 ± 0.01 | 7.33 ± 0.01 |
| LPS | 7.34 ± 0.01 | 7.32 ± 0.01 | 7.30 ± 0.01* | 7.32 ± 0.01 | 7.33 ± 0.01 | 7.31 ± 0.01 | 7.34 ± 0.00 | 7.33 ± 0.01 | 7.33 ± 0.00 | 7.33 ± 0.01 | 7.34 ± 0.01 | |
| ET + LPS | 7.34 ± 0.01 | 7.32 ± 0.01 | 7.32 ± 0.01 | 7.32 ± 0.01 | 7.31 ± 0.01 | 7.31 ± 0.01 | 7.32 ± 0.01 | 7.32 ± 0.01 | 7.33 ± 0.01 | 7.33 ± 0.01 | 7.32 ± 0.02 | |
| PCO2 | Saline | 47.1 ± 1.0 | 48.8 ± 1.6 | 47.2 ± 1.7 | 44.4 ± 3.9 | 48.4 ± 1.3 | 49.0 ± 1.9 | 48.1 ± 1.2 | 48.1 ± 1.5 | 46.1 ± 1.8 | 48.9 ± 1.7 | 50.6 ± 1.9 |
| LPS | 47.1 ± 1.6 | 46.8 ± 1.9 | 48.8 ± 2.4 | 51.9 ± 1.2* | 48.1 ± 2.3 | 48.1 ± 1.4 | 50.7 ± 1.4 | 46.1 ± 1.8 | 45.7 ± 2.0 | 47.6 ± 1.1 | 46.5 ± 0.7 | |
| ET + LPS | 44.1 ± 1.9 | 45.0 ± 2.4 | 44.4 ± 1.8 | 51.3 ± 1.9 | 46.0 ± 2.0 | 47.6 ± 2.3 | 49.6 ± 2.4 | 44.9 ± 1.9 | 44.9 ± 1.6 | 46.1 ± 2.1 | 46.7 ± 1.9 | |
| PO2 | Saline | 22.6 ± 1.12 | 23.7 ± 1.2 | 23.8 ± 1.1 | 22.1 ± 1.4 | 23.9 ± 1.4 | 23.6 ± 1.5 | 22.1 ± 1.3 | 24.2 ± 1.4 | 22.9 ± 1.1 | 21.8 ± 1.2 | 24.0 ± 1.1 |
| LPS | 25.3 ± 1.5 | 27.0 ± 1.8 | 26.2 ± 1.9 | 22.2 ± 2.0 | 26.0 ± 1.8 | 25.0 ± 1.6 | 23.0 ± 1.8 | 26.7 ± 1.7 | 26.0 ± 1.5 | 25.3 ± 1.7 | 28.2 ± 2.3 | |
| ET + LPS | 27.0 ± 1.1 | 27.8 ± 0.8 | 27.5 ± 1.1 | 23.0 ± 1.1 | 27.2 ± 0.7 | 25.5 ± 0.6 | 20.9 ± 2.0 | 27.6 ± 0.8 | 26.3 ± 0.8 | 28.1 ± 1.3 | 27.6 ± 0.8 | |
| Glucose | Saline | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.0 | 0.8 ± 0.0 | 0.7 ± 0.1 | 0.7 ± 0.0 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.0 |
| LPS | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.0 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.0 | 0.9 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | |
| ET + LPS | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.9 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | |
| Lactate | Saline | 0.7 ± 0.1 | 0.8 ± 0.0 | 0.8 ± 0.0 | 0.9 ± 0.0 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.0 | 0.8 ± 0.1 | 0.9 ± 0.1 | 0.8 ± 0.1 |
| LPS | 0.9 ± 0.1 | 0.8 ± 0.1 | 1.5 ± 0.2*# | 2.5 ± 0.6*# | 0.8 ± 0.1 | 1.2 ± 0.2 | 1.3 ± 0.3 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.1 | |
| ET + LPS | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.1 | 1.1 ± 0.1 | 0.7 ± 0.1 | 0.9 ± 0.0 | 1.1 ± 0.2 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | |
Data are means ± SEM. LPS lipopolysaccharide, ET Etanercept, PCO2 partial pressure of arterial carbon dioxide, PO2 partial pressure of arterial oxygen. *P < 0.05 vs control, #P < 0.05 vs ET + LPS