Figure 3.

Exogenous miR-29a in skeletal muscle can attenuate fibrosis progression in the UUO kidney. (A) Masson's trichrome staining of paraffin sections from kidneys of various groups as indicated. The bar graph shows the collagen amount (n = 6). (B) Immunostaining for fibronectin and bar graph showing the amounts of fibronectin in various groups as indicated (n = 6/group). (C) TGF-β1, TGF-β3, YY1, and collagen 1A1 expression in kidney lysates from different groups of mice. The bar graph shows the fold change of each protein band compared with levels in sham mice (represented by a line at onefold). (n = 9/group). TGF-β, transforming growth factor β; UUO, unilateral ureteral obstruction. Color images are available online.