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. Author manuscript; available in PMC: 2020 Mar 23.

Published in final edited form as: Mol Cancer Ther. 2018 Apr 6;17(6):1167–1176. doi: 10.1158/1535-7163.MCT-17-0834

Figure 4. — Characterization of cells resistant to APTO-253. A, Concentration–survival curves for Raji (), Raji/253R (), Raji/253R, and Raji/253R cells after culture in drug-free medium for 3 months (). B, Western blot analysis of proteins involved in apoptosis in Raji and Raji/253R treated with DMSO or APTO-253 0.5 μmol/L for 24 hours. C, The intracellular accumulation of APTO-253 () and Fe(253)₃ () in Raji and Raji/253R cells after a 6-hour exposure to 0.5 μmol/L APTO-253. D, The intracellular accumulation of Fe(253)₃ in the Raji and Raji/253R cells at 6 hours as a function of APTO-253 concentration. Vertical bars, ±SEM. ** P < 0.01; ***, P < 0.001; ****, P < 0.0001.

Inline graphic — Characterization of cells resistant to APTO-253. A, Concentration–survival curves for Raji (), Raji/253R (), Raji/253R, and Raji/253R cells after culture in drug-free medium for 3 months (). B, Western blot analysis of proteins involved in apoptosis in Raji and Raji/253R treated with DMSO or APTO-253 0.5 μmol/L for 24 hours. C, The intracellular accumulation of APTO-253 () and Fe(253)₃ () in Raji and Raji/253R cells after a 6-hour exposure to 0.5 μmol/L APTO-253. D, The intracellular accumulation of Fe(253)₃ in the Raji and Raji/253R cells at 6 hours as a function of APTO-253 concentration. Vertical bars, ±SEM. ** P < 0.01; ***, P < 0.001; ****, P < 0.0001.