Table 3.
Number of grade 1 (G1), grade 2 (G2) and grade 3 (G3) adverse events after treatment of selective internal radiation therapy by 90Y labeled microspheres infusion (90Y SIRT) and mitomycin C (MMC) infusion within 30 days. No grade 3 adverse events occurred after MMC infusion
| Treatment | 90Y SIRT | MMC Cohort A 1x6mg |
MMC Cohort B 1x12mg |
MMC Cohort C 2x12 mg |
MMC Cohort D max 6x12mg |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adverse events | G1 | G2 | G3 | G1 | G2 | G1 | G2 | G1 | G2 | G1 | G2 |
| Clinical | |||||||||||
| Fatigue | 2/16 | - | - | - | - | - | - | 3/3 | - | 2/6 | - |
| Pain | 5/16 | 2/16 | - | - | - | - | - | - | - | 1/6 | - |
| Nausea | 3/16 | 2/16 | - | - | - | - | - | - | - | 1/6 | - |
| Emesis | 2/16 | 2/16 | - | - | - | - | - | - | - | 1/6 | - |
| Gastrointestinal ulcer | - | 4/16 | 1/16 | - | - | - | - | - | - | - | - |
| Biochemical | |||||||||||
| Leukopenia | 2/16 | - | - | - | - | - | - | 2/3 | - | 4/6 | 2/6 |
| Thrombocytopenia | 3/16 | 1/16 | - | 1/2 | - | 1/1 | - | 3/3 | - | 4/6 | 2/6 |
| Anaemia | - | - | - | - | - | - | - | - | - | 4/6 | - |
| Increased aspartate aminotransferase | 5/16 | 1/16 | - | - | - | - | - | - | - | 2/6 | - |
| Increased alanine aminotransferase | 3/16 | 1/16 | - | - | - | - | - | - | - | 1/6 | - |
| Increased bilirubin | - | - | - | - | - | - | - | 1/3 | 1/3 | - | - |
| Increased alkaline phosphatase | 2/16 | 1/16 | - | - | - | - | - | 1/3 | - | 2/6 | - |
| Decreased eGFR | - | 1/16 | - | - | - | - | - | - | - | - | - |
| Increased gamma-glutamyl transferase | 4/16 | 1/16 | - | - | - | - | - | 1/3 | - | 4/6 | - |
eGFR = estimated glomerular filtration rate